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Jürgen Knoblich

Date and Place of Birth	October 24, 1963 in Memmingen, Germany
Nationality	German
Present Address	Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) Dr. Bohr Gasse 3 1030 Vienna, Austria
Telephone	+43 1 790 44 4800
E-Mail
Website	http://www.imba.oeaw.ac.at/research/juergen-knoblich/

Professional Experience

01/05-current	Deputy Director Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna
01/04-current	Senior Scientist Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna
09/97-01/04	Group Leader Institute of Molecular Pathology (I.M.P.), Vienna
07/94-09/97	Post-Doctoral Position University of California, San Francisco Laboratory of Drs. Lily and Yuh Nung Jan

Education

10/90-06/94	Ph.D. Thesis: Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tübingen Laboratory of Dr. Christian Lehner Genetic Analysis of Cyclin Proteins During Drosophila Embryonic Development
07/89-09/90	Diploma Thesis: Max Planck Institute for Developmental Biology, Tübingen Dept. of Prof. Dr. Alfred Gierer Identification of a Novel Member of the Immunoglobulin Protein Superfamily Expressed in the CNS of Drosophila melanogaster
10/83-07/89	Program in Biochemistry University of Tübingen
10/86-10/87	University College London Laboratory Courses in Molecular Biology and Biochemistry

Awards and Fellowships

2012	Erwin Schroedinger Prize (2012) Austrian Academy of Sciences (ÖAW)
2010	Advanced Research Grant (2010) European Research Council (ERC)
2009	Wittgenstein Prize (2009) Austrian Science Fund (FWF)
2003	Early Career Award European Life Scientist Organization (ELSO)
2001	Young Investigator Award European Molecular Biology Organisation (EMBO)
2001	Anniversary Award Federation of the European Biochemical Societies (FEBS)
1994	Postdoctoral Fellowship (07/94-07/96) European Molecular Biology Organisation (EMBO)
1996	Postdoctoral Fellowship (07/96 - 09/97) Howard Hughes Medical Institute

Memberships

2014	EMBO council, elected member
2013	Austrian Academy of Sciences
2012	Academia Europaea
2005-2013	EMBO fellowship committee (Chairperson 2010 - 2013)
2009	Editorial Board Current Opinion in Cell Biology
2008-2011	Scientific Advisory Board, Cancer Stem Cell Network, Deutsche Krebshilfe e.V. (German Cancer Aid)
2004	Editorial Board, European Journal of Cell Biology
2002	Editorial Board, Current Biology
2002	EMBO (European Molecular Biology Organisation), elected member
2002	ISSCR (International Society for Stem Cell Research), Member

Ten most relevant Publications

Betschinger, J., Mechtler, K. and Knoblich, J.A. (2003). The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature, 422, 326-330.

Emery, G., Hutterer, A., Berdnik, D., Mayer, B., Wirtz-Peitz, F., Gonzalez Gaitan, M., and Knoblich, J. A. (2005). Asymmetric rab11 endosomes regulate Delta recycling and specify cell fate in the Drosophila nervous system. Cell 122, 763-773.

Betschinger, J., Mechtler, K., and Knoblich, J. A. (2006). Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124, 1241-1253.

Neumüller, R.A., Betschinger, J., Fischer, A., Bushati, N., Poernbacher, I., Mechtler, K., Stephen M. Cohen, S.M. and Knoblich, J.A. (2008). Mei-P26 regulates micro RNAs and cell growth in the Drosophila ovarian stem cell lineage, Nature, 454, 241-245.

Wirtz-Peitz, F., Nishimura, T., and Knoblich, J.A. (2008). Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization, Cell, 135, 161-173.

Schwamborn, J.C. Berezikov, E., and Knoblich, J.A. (2009). The Brat homolog TRIM32 Prevents Self-renewal in Neural Progenitors by Degrading c-Myc and Activating Micro-RNAs, Cell, 136, 913-925.

Mummery-Widmer, J.L., Yamazaki, M., Stoeger, T., Novatchkova, M., Chen, D., Dietzl, G., Dickson, B.J., and Knoblich, J.A. (2009) Genome-wide analysis of Drosophila external sensory organ development by transgenic RNAi, Nature, 458, 987-992.

Lancaster, M. A., Renner, M., Martin, C. A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., and Knoblich, J. A. (2013). Cerebral organoids model human brain development and microcephaly. Nature 501, 373-379.

Eroglu, E., Burkard, T. R., Jiang, Y., Saini, N., Homem, C. C., Reichert, H., and Knoblich, J. A. (2014). SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells. Cell 156, 1259-1273.

Homem, C. C., Steinmann, V., Burkard, T. R., Jais, A., Esterbauer, H., and Knoblich, J. A. (2014). Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells. Cell 158, 874-888.

Publications (complete list)

Marchetti, G., Reichardt, I., Knoblich, JA., Besse, F. (2014). The TRIM-NHL Protein Brat Promotes Axon Maintenance by Repressing src64B Expression. J Neurosci. 34(41):13855-64

Lancaster, MA., Knoblich, JA. (2014). Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc. 9(10):2329-40

Mauri, F., Reichardt, I., Mummery-Widmer, J. L., Yamazaki, M., and Knoblich, J. A. (2014). The Conserved Discs-large Binding Partner Banderuola Regulates Asymmetric Cell Division in Drosophila. Curr Biol 24, 1811-1825.

Yasugi, T., Fischer, A., Jiang, Y., Reichert, H., and Knoblich, J. A. (2014). A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells. PLoS One 9, e97034.

Williams, SE., Ratliff, LA., Postiglione, MP., Knoblich, JA., Fuchs, E. (2014). Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 16, 758-769.

Ayukawa, T., Akiyama, M., Mummery-Widmer, JL., Stoeger, T., Sasaki, J., Knoblich, JA., Senoo, H., Sasaki, T., Yamazaki, M. (2014). Dachsous-Dependent Asymmetric Localization of Spiny-Legs Determines Planar Cell Polarity Orientation in Drosophila. Cell Rep. 8, 610-621.

Lancaster, M. A., and Knoblich, J. A. (2014). Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345, 1247125.

Hagelkruys, A., Lagger, S., Krahmer, J., Leopoldi, A., Artaker, M., Pusch, O., Zezula, J., Weissmann, S., Xie, Y., Schofer, C., Schlederer, M., Brosch, G., Matthias, P., Selfridge, J., Lassmann, H., Knoblich, J. A., and Seiser, C. (2014). A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. Development 141, 604-616.

Jüschke, C., Dohnal, I., Pichler, P., Harzer, H., Swart, R., Ammerer, G., Mechtler, K., Knoblich, JA. (2013). Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation. Genome Biol. 14(11):R133

Bardet, A. F., Steinmann, J., Bafna, S., Knoblich, J. A., Zeitlinger, J., and Stark, A. (2013). Identification of transcription factor binding sites from ChIP-seq data at high resolution. Bioinformatics 29, 2705-2713.

Homem, CC., Reichardt, I., Berger, C., Lendl, T., Knoblich, JA. (2013). Long-Term Live Cell Imaging and Automated 4D Analysis of Drosophila Neuroblast Lineages. PLoS One. 8(11):e79588

Jüschke, C., Xie, Y., Postiglione, M. P., and Knoblich, J. A. (2013). Analysis and modeling of mitotic spindle orientations in three dimensions. Proc Natl Acad Sci U S A

Xie, Y., Jüschke, C., Esk, C., Hirotsune, S., Knoblich, JA. (2013). The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex. Neuron. 79(2):254-65

Reichardt, I., Knoblich, JA. (2013). Cell biology: Notch recycling is numbed. Curr Biol. 23(7):R270-2

Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, M., Knoblich, J. A., and van Lohuizen, M. (2013). The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. EMBO J 32, 1598-1612.

Harzer, H., Berger, C., Conder, R., Schmauss, G., Knoblich, JA. (2013). FACS purification of Drosophila larval neuroblasts for next-generation sequencing. Nat Protoc. 8(6):1088-99

Homem, CC., Knoblich, JA. (2012). Drosophila neuroblasts: a model for stem cell biology. Development 139(23):4297-310

Goulas, S., Conder, R., Knoblich, JA. (2012). The par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell 11(4):529-40

Berger, C., Harzer, H., Burkard, TR., Steinmann, J., van der Horst, S., Laurenson, AS., Novatchkova, M., Reichert, H., Knoblich, JA. (2012). FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal. Cell Rep. 2(2):407-18

Lancaster, M.A., Knoblich J.A. (2012). Spindle orientation in mammalian cerebral cortical development. Curr Opin Neurobiol 22, 737-746.

Postiglione, M. P., Juschke, C., Xie, Y., Haas, G. A., Charalambous, C., and Knoblich, J. A. (2011). Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex. Neuron 72, 269-284.

Richter, C., Oktaba, K., Steinmann, J., Muller, J., and Knoblich, J. A. (2011). The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol 13, 1029-1039.

Neumüller R.A., Constance Richter, C., Fischer, A., Novatchkova, M., Neumüller, K.G. and Knoblich, J.A. (2011) Genome wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell 8, 580-593.

Khazaei, M. R., Bunk, E. C., Hillje, A. L., Jahn, H. M., Riegler, E. M., Knoblich, J. A., Young, P., and Schwamborn, J. C. (2011). The E3-ubiquitin ligase TRIM2 regulates neuronal polarization. J Neurochem 117, 29-37.

Knoblich, J. A. (2010). Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol 11, 849-860.

Neumüller, R.A. and Knoblich, J.A. (2009). Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev 23, 2675-2699.

Conder, R., and Knoblich, J. A. (2009). Fly stem cell research gets infectious. Cell 137, 1185-1187.

Neumuller, R. A., and Knoblich, J. A. (2009). Wicked views on stem cell news. Nat Cell Biol 11, 678-679.

Coumailleau, F., Fürthauer, M., Knoblich, J.A. and González-Gaitán, M. (2009). Directional Delta/Notch trafficking in asymmetric Sara endosomes during asymmetric cell division. Nature, 458, 1051-1055.

Schwamborn, J.C. Berezikov, E., and Knoblich, J.A. (2009). The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors, Cell, 136, 913-925.

Barral, Y., and Knoblich, J. (2008). Cell division, growth and death (Editorial Overview). Curr Opin Cell Biol 20, 647-649.

Benetka, W., Mehlmer, N., Maurer-Stroh, S., Sammer, M., Koranda, M., Neumuller, R., Betschinger, J., Knoblich, J. A., Teige, M., and Eisenhaber, F. (2008). Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling. Cell Cycle 7, 3709-3719.

Wirtz-Peitz, F., Nishimura, T., and Knoblich, J.A. (2008). Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization, Cell, 135, 161-173.

Speicher, S., Fischer, A., Knoblich, J. A., and Carmena, A. (2008) The PDZ Protein Canoe Regulates the Asymmetric Division of Drosophila Neuroblasts and Muscle Progenitors . Curr Biol, 18, 831-837.

Bowman, S. K., Rolland, V., Betschinger, J., Kinsey, K. A., Emery, G., and Knoblich, J. A. (2008). The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila. Dev Cell, 14, 535-546.

Schwamborn, J.C. amd Knoblich, J.A. (2008) Lis1 and spindle orientation in neuroepithelial cells. Cell Stem Cell, 2, 193-194.

Knoblich, J.A. (2008) Mechanisms of Asymmetric Stem Cell Division, Cell, 132, 583-597.

Jüschke, C. and Knoblich, J.A. (2008) Purification of Drosophila Protein Complexes for Mass Spectrometry, Methods Mol Biol., 420, 347-58.

Knoblich, J.A. (2007) On the backroads to cellular asymmetry, Development 134, 4311-4313.

Knoblich, J. A. (2006). Cell biology. Sara splits the signal. Science 314, 1094-1096.

Gallagher, C. and Knoblich, J.A. (2006) The conserved C2 domain protein Lethal (2) giant discs regulates protein trafficking in Drosophila. Dev Cell, 11, 641-653.

Emery, G. and Knoblich, J.A. (2006). Endosome dynamics during development. Curr Opin Cell Biol, 18, 407-415.

Hutterer, A., Berdnik, D., Wirtz-Peitz, F., Zigman, M., Schleiffer, A. and Knoblich, J. A. (2006). Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell, 11, 147-157.

Bowman, S. K., Neumuller, R. A., Novatchkova, M., Du, Q., and Knoblich, J. A. (2006). The Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division. Dev Cell 10, 731-742.

Wirtz-Peitz, F., and Knoblich, J. A. (2006). Lethal giant larvae take on a life of their own. Trends Cell Biol 16, 234-241.

Betschinger, J., Mechtler, K., and Knoblich, J. A. (2006). Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124, 1241-1253.

Vishnu, S., Hertenstein, A., Betschinger, J., Knoblich, J. A., Gert de Couet, H., and Fischbach, K. F. (2006). The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. Dev Biol 289, 296-307

Knoblich, J.A. (2005) Pins for Spines. Nature Cell Biology, 7, 1057-1058.

Zigman, M., Cayouette, M., Charalambous, C., Schleiffer, A., Hoeller, O., Dunican, D., McCudden, C.R., Firnberg, R., Barres, B.A., Siderovski, D.P. and Knoblich, J.A. (2005) Mammalian Inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron, 48, 539-545.

Mayer, B., Emery, G., Berdnik, D., Wirtz-Peitz, F. and Knoblich, J.A.. (2005) Quantitative analysis of protein dynamics during asymmetric cell division. Curr Biol, 15, 1847-1854.

Hampoelz, B., Hoeller, O., Bowman, S.K., Dunican, D., and Knoblich, J.A. (2005) Drosophila Ric-8 is essential for plasma membrane localization of heterotrimeric G proteins. Nature Cell Biology, 7, 1099-1105.

Jafar-Nejad, H., Andrews, H. K., Acar, M., Bayat, V., Wirtz-Peitz, F., Mehta, S. Q., Knoblich, J. A., and Bellen, H. J. (2005). Sec15, a Component of the Exocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Organ Precursors. Dev Cell 9, 351-363.

Bhalerao, S., Berdnik, D., Torok, T., and Knoblich, J. A. (2005). Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr Biol 15, 1583-1590.

Hutterer, A., and Knoblich, J. A. (2005). Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep 6, 836-842.

Zarnescu, D. C., Jin, P., Betschinger, J., Nakamoto, M., Wang, Y., Dockendorff, T. C., Feng, Y., Jongens, T. A., Sisson, J. C., Knoblich, J. A., Warren, S. T., and Moses, K. (2005). Fragile x protein functions with lgl and the par complex in flies and mice. Dev Cell 8, 43-52.

Betschinger, J., Eisenhaber, F., and Knoblich, J. A. (2005). Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae. Curr Biol 15, 276-282.

Knoblich, J. A. (2005). Neurobiology: getting axons going. Nature 436, 632-633.

Hampoelz, B., and Knoblich, J. A. (2004). Heterotrimeric G proteins: new tricks for an old dog. Cell 119, 453-456.

Betschinger, J., and Knoblich, J. A. (2004). Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates. Curr Biol 14, R674-685.

Hutterer, A., Betschinger, J., Petronczki, M., and Knoblich, J. A. (2004). Sequential Roles of Cdc42, Par-6, aPKC, and Lgl in the Establishment of Epithelial Polarity during Drosophila Embryogenesis. Dev Cell 6, 845-854.

Subramanian, A., Prokop, A., Yamamoto, M., Sugimura, K., Uemura, T., Betschinger, J., Knoblich, J. A., and Volk, T. (2003). Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction. Curr Biol 13, 1086-1095.

Blumer, J. B., Bernard, M. L., Peterson, Y. K., Nezu, J., Chung, P., Dunican, D. J., Knoblich, J. A., and Lanier, S. M. (2003). Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. J Biol Chem 278, 23217-23220.

Betschinger, J., Mechtler, K. and Knoblich, J.A. (2003). The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature, 422, 326-330.

Berdnik, D., Török, T., González-Gaitán, M., and Knoblich, J. A. (2002). The Endocytic Protein -Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila. Developmental Cell, 3, 221-231.

Berdnik, D. and Knoblich, J. A. (2002). Drosophila Aurora-A is required for centrosome maturation and actin dependent asymmetric protein localization during mitosis. Current Biology, 12, 640-647.

Tekotte, H. Berdnik, D., Török, T., Buszczak, M., Jones, L. M., Cooley, L., Knoblich, J. A. and Davis, I (2002). dcas is required for importin-3 nuclear export and mechano-sensory organ cell fate specification in Drosophila. Developmental Biology, 244, 396-406.

Knoblich, J. A. (2001). The Drosophila nervous system as a model for asymmetric cell division. Symp. Soc. Exp. Biol. 53, 75-89.

Schaefer, M., Petronczki, M., Dorner, D., Forte, M. and Knoblich, J.A. (2001). Heterotrimeric G-Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System. Cell, 107, 183-194.

Huynh, J. R., Petronczki, M, Knoblich, J. A., and St Johnston D. (2001). Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila. Curr Biol. 11, 901-906.

Schaefer, M. and Knoblich, J. A. (2001). Protein Localization during Asymmetric Cell Division. Experimental Cell Research, 271, 66-74.

Bulgheresi, S., Kleiner, E. and Knoblich, J.A. (2001). Inscuteable dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division. Journal of Cell Science, 114, 3655-3662.

Knoblich, J. A. (2001). Asymmetric Cell Division During Animal Development. Nature Reviews Molecular Cell Biology, 2, 11-20.

Knoblich, J.A. (2001). The Drosophila nervous system as a model for asymmetric cell division. In: Brain Stem Cells. Ed. Miyan, J., Beesley, P. and Thorndyke, M. (BIOS Scientific Publishers, Oxford). 75-89.

Petronczki, M. and Knoblich, J.A. (2001). DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nature Cell Biology, 3, 43-49.

Knoblich, J.A. (2000). Epithelial polarity: The ins and outs of the fly epidermis. Current Biology, 10, R791-794.

Schaefer, M., Shevchenko, A., Shevchenko, A. and Knoblich, J. A. (2000). A protein complex containing Inscuteable and the G alpha binding protein Pins is implicated in orienting asymmetric cell divisions in Drosophila. Current Biology, 10, 353-362.

Schober, M., Schaefer, M., and Knoblich, J.A. (1999). Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402, 548-551.

Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1999). Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. Current Biology 11, 155-158.

Glotzer, M. and Knoblich, J.A. (1998). Cell multiplication (editorial overview). Current Opinion in Cell Biology 10, 739-741.

Jacobs, H., Knoblich, J.A., and Lehner, C.F. (1998). Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes and Development 12, 3741-3751.

Shen, C. P., Knoblich, J. A., Chan, Y. M., Jiang, M. M., Jan, L. Y., and Jan, Y. N. (1998). Miranda as a multidomain adapter linking apically localized inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. Genes and Development 12, 1837-46.

Knoblich, J. A., Jan, L. Y., and Jan, Y. N. (1997). The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization. Proc Natl Acad Sci U S A 94, 13005-10.

Knoblich, J. A., Jan, L. Y., and Jan, Y. N. (1997). Asymmetric segregation of the Drosophila Numb protein during mitosis: facts and speculations. Cold Spring Harb Symp Quant Biol 62, 71-7.

Knoblich, J. A. (1997). Mechanisms of asymmetric cell division during animal development. Curr Opin Cell Biol 9, 833-41.

Frise, E., Knoblich, J.A., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1996). The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. PNAS 93, 11925-11932.

Kraut, R., Chia, W., Jan, L.Y., Jan, Y.N., and Knoblich, J.A. (1996). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383, 50-55.

Knoblich, J.A., Jan, L.Y. and Jan, Y.N. (1995). Asymmetric segregation of Numb and Prospero during cell division. Nature 377, 624-627.

Rhyu, M.S. and Knoblich, J.A. (1995). Spindle orientation and asymmetric cell fate. Cell 82, 523-526.

Sauer, K., Knoblich, J.A., Richardson, H. and Lehner, C.F. (1995). Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes and Development 9, 1327-1329.

Kreutzer, M.A., Richards, J.P., De Silva-Udawatta, M.N., Temenak, J.J., Knoblich, J.A., Lehner, C.F., and Bennett, K.L. (1995). Caenorhabditis elegans cyclin A- and B-type genes: A cyclin A multigene family, an ancestral cyclin B3 and differential germline expression. Journal of Cell Science 108, 2415-2424.

Knoblich, J.A., Sauer, K., Jones, L., Richardson, H., Saint, R. and Lehner, C.F. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77, 107-129.

Knoblich, J.A. and Lehner, C.F. (1993). Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO Journal 12, 65-74.

Lehner, C.F., Ried, G., Stern, B. and Knoblich, J.A. (1992). Cyclins and cdc2 kinases in Drosophila: genetic analyses in a higher eukaryote. Ciba Foundation Symposium 170, 97-109.

FEBS 2015, 40th FEBS Congress - The Biochemical Basis of Life

Berlin, Germany - July 4-9, 2015